Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trials

1 Jun 2025

Abstract excerpt

Cell-based gene therapies, including chimeric antigen receptor-T, T-cell receptor-T, and tumor-infiltrating lymphocyte therapies, have transformed the treatment landscape for certain cancers, yet their efficacy in solid tumors remains limited. Next-generation therapies aim to overcome biological barriers, enhance potency and safety, and streamline development timelines through innovative approaches. Recent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Nanowire Synthesis and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40480658
DOI: 10.1136/jitc-2024-011301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intentional heterogeneity in autologous cell-based gene therapies: strategic considerations for first-in-human trialsPMID 40480658Read ↗

Genome Editing in Engineered T Cells for Cancer ImmunotherapySemantic proximity Read ↗

Multiplexed engineering and precision gene editing in cellular immunotherapySemantic proximity Read ↗

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuitsSemantic proximity Read ↗

In Vivo Gene Editing: A Healthcare Revolution in the MakingSemantic proximity Read ↗

From "Simulation" to "Mirror": Gene editing and humanization redefines the next-generation precision oncology animal model.Semantic proximity Read ↗

Engineering strategies to safely drive CAR T-cells into the futureSemantic proximity Read ↗

Leveraging Single-Cell Sequencing for Chimeric Antigen Receptor T Cell TherapiesSemantic proximity Read ↗

SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple lociSemantic proximity Read ↗

Engineering the next generation of allogeneic CAR cells: iPSCs as a scalable and editable platformSemantic proximity Read ↗

Comprehensive genome editing confers ‘off-the-shelf’ CAR-T cells superior efficacy against solid tumorsSemantic proximity Read ↗

Delivery technologies for T cell gene editing: Applications in cancer immunotherapySemantic proximity Read ↗

Use of Cell and Genome Modification Technologies to Generate Improved “Off-the-Shelf” CAR T and CAR NK CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.