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Article

Programmable sequential mutagenesis by inducible Cpf1 crRNA array inversion.

Nature communications - 15 May 2018

Chow Ryan D, Kim Hyunu Ray, Chen Sidi

Abstract excerpt

Mutations and genetic alterations are often sequentially acquired in various biological and pathological processes, such as development, evolution, and cancer. Certain phenotypes only manifest with precise temporal sequences of genetic events. While multiple approaches have been developed to model the effects of mutations in tumorigenesis, few recapitulate the stepwise nature of cancer evolution. Here we describe...

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Identifiers

PMID: 29765043
DOI: 10.1038/s41467-018-04158-z
PMCID: PMC5954137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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