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Article

Thiopurines correct the effects of autophagy impairment on intestinal healing - a potential role for ARHGAP18/RhoA.

Disease models & mechanisms - 1 Apr 2021

Prins Marileen M C, Giugliano Francesca P, van Roest Manon, van de Graaf Stan F J, Koelink Pim J, Wildenberg Manon E

Abstract excerpt

The ATG16L1 T300A single-nucleotide polymorphism (SNP) is associated with Crohn's disease and causes an autophagy impairment. We have previously shown that this SNP is involved in the migration and hyperactivation of Rac1 in dendritic cells. Mucosal healing, currently the main target for inflammatory bowel disease treatment, depends on restoration of the epithelial barrier and requires appropriate migration of...

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Identifiers

PMID: 33973626
DOI: 10.1242/dmm.047233
PMCID: PMC8084572

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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