Article
The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines.
Mucosal immunology - 1 Mar 2017
Wildenberg M E, Koelink P J, Diederen K, Te Velde A A, Wolfkamp S C S, Nuij V J, Peppelenbosch M P, Nobis M, Sansom O J, Anderson K I, van der Woude C J, D'Haens G R A M, van den Brink G R
Abstract excerpt
Thiopurines are commonly used drugs in the therapy of Crohn's disease, but unfortunately only show a 30% response rate. The biological basis for the thiopurine response is unclear, thus hampering patient selection prior to treatment. A genetic risk factor associated specifically with Crohn's disease is a variant in ATG16L1 that reduces autophagy. We have previously shown that autophagy is involved in dendritic...
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