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Article

The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats.

Physiological genomics - 1 Jun 2021

Chesney Kari L, Men Hongsheng, Hankins Miriam A, Bryda Elizabeth C

Abstract excerpt

ATG16L1 is a ubiquitous autophagy gene responsible, in part, for formation of the double-membrane bound autophagosome that delivers unwanted cellular debris and intracellular pathogens to the lysosome for degradation. A single, nonsynonymous adenine to guanine polymorphism resulting in a threonine to alanine amino acid substitution (T300A) directly preceded by a caspase cleavage site (DxxD) causes an increased...

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Source

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Identifiers

PMID: 33818130
DOI: 10.1152/physiolgenomics.00114.2020
PMCID: PMC8285577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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