Article
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis.
Gastroenterology - 1 Aug 2011
Muise Aleixo M, Walters Thomas, Xu Wei, Shen-Tu Grace, Guo Cong-Hui, Fattouh Ramzi, Lam Grace Y, Wolters Victorien M, Bennitz Joshua, van Limbergen Johan, Renbaum Paul, Kasirer Yair, Ngan Bo-Yee, Turner Dan, Denson Lee A, Sherman Philip M, Duerr Richard H, Cho Judy, Lees Charlie W, Satsangi Jack, Wilson David C, Paterson Andrew D, Griffiths Anne M, Glogauer Michael, Silverberg Mark S, Brumell John H
Abstract excerpt
BACKGROUND & AIMS: RAC1 is a guanosine triphosphatase that has an evolutionarily conserved role in coordinating immune defenses, from plants to mammals. Chronic inflammatory bowel diseases are associated with dysregulation of immune defenses. We studied the role of RAC1 in inflammatory bowel diseases using human genetic and functional studies and animal models of colitis. METHODS: We used a candidate gene...
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