Article

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

2021-01-05

Abstract excerpt

There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. In the present study, we found that recombinant human interferon-alpha (IFNa) triggers intrinsic and extrinsic cellular antiviral responses, as well as reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro. Although IFNa alone was insufficient to completely abolish SARS-...

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Literature Corpus work: e2ed6b24-8091-5ac6-ad66-69d689eb7891
DOI: 10.1101/2021.01.05.425331

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