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Article

BTLA Expression and Function Are Impaired on SLE B Cells.

Frontiers in immunology - 1 Jan 2021

Wiedemann Annika, Lettau Marie, Weißenberg Sarah Y, Stefanski Ana-Luisa, Schrezenmeier Eva-Vanessa, Rincon-Arevalo Hector, Reiter Karin, Alexander Tobias, Hiepe Falk, Lino Andreia C, Dörner Thomas

Abstract excerpt

B- and T-lymphocyte attenuator (BTLA/CD272) is an inhibitory checkpoint molecule expressed on T and B cells. Prior studies reported defective function of BTLA by T cells in patients with systemic lupus erythematosus (SLE), whereas nothing is known about its role on B cells in SLE, a disease with various B cell abnormalities. Peripheral blood mononuclear cells (PBMCs) from 23 healthy donors (HD) and 34 SLE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33968071
DOI: 10.3389/fimmu.2021.667991
PMCID: PMC8100666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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