Article
Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95.
Arthritis and rheumatism - 1 Jun 2008
Jacobi Annett M, Reiter Karin, Mackay Meggan, Aranow Cynthia, Hiepe Falk, Radbruch Andreas, Hansen Arne, Burmester Gerd-R, Diamond Betty, Lipsky Peter E, Dörner Thomas
Abstract excerpt
OBJECTIVE: Analysis of peripheral B cell subsets in patients with systemic lupus erythematosus (SLE) has provided evidence of specific alterations, such as an expansion of CD27++ plasma cells/blasts and transitional B cells. However, memory B cells in lupus have not been thoroughly investigated, and only recently a CD27- memory B cell subset was identified in the peripheral blood of lupus patients. Focusing on...
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