Article

IL-21-STAT3 axis negatively regulates LAIR1 expression in B cells

2025-01-18

Abstract excerpt

LAIR1 is an inhibitory receptor broadly expressed on human immune cells, including B cells. LAIR1 has been shown to modulate BCR signaling, however, it is still unclear whether its suppressive activity can be a negative regulator for autoreactivity. In this study, we demonstrate the LAIR1 expression profile on human B cells and prove its regulatory function and relationships to B cell autoreactivity. We show that...

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Literature Corpus work: f1298e54-8ac0-5640-8223-8d1a4d45d8e6
DOI: 10.1101/2025.01.14.632971

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