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Article

Rituximab in Systemic Lupus Erythematosus: Transient Effects on Autoimmunity Associated Lymphocyte Phenotypes and Implications for Immunogenicity.

Frontiers in immunology - 1 Jan 2022

Faustini Francesca, Sippl Natalie, Stålesen Ragnhild, Chemin Karine, Dunn Nicky, Fogdell-Hahn Anna, Gunnarsson Iva, Malmström Vivianne

Abstract excerpt

B cell abnormalities are common in systemic lupus erythematosus (SLE), and include expansion of double negative (DN) and age-associated-like B cells (ABC-like). We aimed to investigate rituximab (RTX) effects on DN and ABC-like B-cell subsets and, when possible, also secondary effects on T cells. Fifteen SLE patients, fulfilling the ACR 1982 criteria, starting RTX and followed longitudinally up to two years, were...

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Identifiers

PMID: 35464461
DOI: 10.3389/fimmu.2022.826152
PMCID: PMC9027571

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