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Article

RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes.

PLoS genetics - 1 Feb 2021

Shen Qingtang, Wang Yifan E, Truong Mathew, Mahadevan Kohila, Wu Jingze J, Zhang Hui, Li Jiawei, Smith Harrison W, Smibert Craig A, Palazzo Alexander F

Abstract excerpt

Mutations in RanBP2 (also known as Nup358), one of the main components of the cytoplasmic filaments of the nuclear pore complex, contribute to the overproduction of acute necrotizing encephalopathy (ANE1)-associated cytokines. Here we report that RanBP2 represses the translation of the interleukin 6 (IL6) mRNA, which encodes a cytokine that is aberrantly up-regulated in ANE1. Our data indicates that soon after...

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Identifiers

PMID: 33600493
DOI: 10.1371/journal.pgen.1009378
PMCID: PMC7924746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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