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Article

The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference.

PloS one - 1 Jan 2013

Aqil Madeeha, Naqvi Afsar Raza, Bano Aalia Shahr, Jameel Shahid

Abstract excerpt

The HIV-1 accessory protein Nef is an important virulence factor. It associates with cellular membranes and modulates the endocytic machinery and signaling pathways. Nef also increases the proliferation of multivesicular bodies (MVBs), which are sites for virus assembly and budding in macrophages. The RNA interference (RNAi) pathway proteins Ago2 and GW182 localize to MVBs, suggesting these to be sites for...

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Share to Amino Acid Motifs
Share to Argonaute Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conserved Sequence

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Share to nef Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 24023945
DOI: 10.1371/journal.pone.0074472
PMCID: PMC3762824

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