Article

XRN2-mediated regulation of tumor suppressor microRNAs is of critical pathophysiological significance in Humans

2021-08-20

Abstract excerpt

MicroRNAs (miRNAs) are critical regulators of diverse developmental and physiological processes, and they themselves get regulated both at the level of biogenesis and turnover. We demonstrate that the ribonuclease XRN2 can degrade the mature forms of certain let-7 family members in multiple human cancer cell lines, without affecting their precursors. XRN2 also affects the accumulation of several other tumor suppre...

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Literature Corpus work: f57a1f38-b564-5bc2-b8b9-9a591843ea12
DOI: 10.1101/2021.08.20.457117

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