Article
Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia.
Cancer chemotherapy and pharmacology - 1 Aug 2021
Youssef Yomna H, Makkeyah Sara M, Soliman Ahmed F, Meky Nefissa H
Abstract excerpt
BACKGROUND: Asparaginase (ASNase) is a key component in the treatment protocols of childhood acute lymphoblastic leukemia (ALL). Asparagine synthetase (ASNS) and the basic region leucine zipper activating transcription factor 5 (ATF5) mediate the anti-leukemic effect of ASNase. Only a few reports studied the association between polymorphisms in these genes and treatment-related toxicity and response. Therefore,...
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