Article
Phosphorylation of the WH2 domain in yeast Las17/WASP regulates G-actin binding and protein function during endocytosis.
Scientific reports - 6 May 2021
Tyler J J, Smaczynska-de Rooij I I, Abugharsa L, Palmer J S, Hancock L P, Allwood E G, Ayscough K R
Abstract excerpt
Actin nucleation is the key rate limiting step in the process of actin polymerization, and tight regulation of this process is critical to ensure actin filaments form only at specific times and at defined regions of the cell. WH2 domains are short sequence motifs found in many different actin binding proteins including WASP family proteins which regulate the actin nucleating complex Arp2/3. In this study we...
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