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Article

Cellular functions of WASP family proteins at a glance

23 Jun 2017

Abstract excerpt

Proteins of the Wiskott-Aldrich syndrome protein (WASP) family function as nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives the generation of branched actin filaments. Arp2/3-generated actin regulates diverse cellular processes, including the formation of lamellipodia and filopodia, endocytosis and/or phagocytosis at the plasma membrane, and the generation of cargo-laden...

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PMID: 28646090
DOI: 10.1242/jcs.199570

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