Article
The F-BAR protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation.
Current biology : CB - 15 Dec 2009
Boettner Douglas R, D'Agostino Jessica L, Torres Onaidy Teresa, Daugherty-Clarke Karen, Uygur Aysu, Reider Amanda, Wendland Beverly, Lemmon Sandra K, Goode Bruce L
Abstract excerpt
BACKGROUND: Actin polymerization by Arp2/3 complex must be tightly regulated to promote clathrin-mediated endocytosis. Although many Arp2/3 complex activators have been identified, mechanisms for its negative regulation have remained more elusive. To address this, we analyzed the yeast arp2-7 allele, which is biochemically unique in causing unregulated actin assembly in vitro in the absence of Arp2/3 activators....
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