Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis.

The Journal of biological chemistry - 13 Jun 2008

Daugherty Karen M, Goode Bruce L

Abstract excerpt

The Arp2/3 complex is comprised of seven evolutionarily conserved subunits and upon activation by WASp or another nucleation promoting factor nucleates the formation of actin filaments. These events are critical for driving a wide range of cellular processes, including motility, endocytosis, and intracellular trafficking. However, an in depth understanding of the Arp2/3 complex activation and nucleation mechanism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin-Related Protein 2-3 Complex
Share to Actins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Dose-Response Relationship, Drug

Share to Endocytosis

Share to Molecular Conformation

Share to Mutagenesis

Share to Plasmids

Source

Open in PubMed Open full text

Identifiers

PMID: 18381280
DOI: 10.1074/jbc.M800783200
PMCID: PMC2423265

Genes

ARPC2
ARPC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis.PMID 18381280Read ↗

Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function.Semantic proximity Read ↗

Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex.Semantic proximity Read ↗

Molecular analysis of Arp2/3 complex activation in cells.Semantic proximity Read ↗

A mutant of Arp2p causes partial disassembly of the Arp2/3 complex and loss of cortical actin function in fission yeast.Semantic proximity Read ↗

The F-BAR protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation.Semantic proximity Read ↗

Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation.Semantic proximity Read ↗

Functional interactions between the p35 subunit of the Arp2/3 complex and calmodulin in yeast.Semantic proximity Read ↗

Direct comparison of clathrin-mediated endocytosis in budding and fission yeast reveals conserved and evolvable featuresSemantic proximity Read ↗

Distinct Actin and Lipid Binding Sites in Ysc84 Are Required during Early Stages of Yeast Endocytosis.Semantic proximity Read ↗

Dissection of Arp2/3 complex actin nucleation mechanism and distinct roles for its nucleation-promoting factors in Saccharomyces cerevisiae.Semantic proximity Read ↗

Phosphorylation of the WH2 domain in yeast Las17/WASP regulates G-actin binding and protein function during endocytosis.Semantic proximity Read ↗

Direct Actin Monomer Delivery is a WASP-specific Requirement for Arp2/3 Complex Activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.