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Article

WASP family proteins: Molecular mechanisms and implications in human disease

1 Jun 2022

Abstract excerpt

Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic mutations or misregulation of these proteins are tightly associated with many diseases. The WASP-family proteins act by transmitting various upstream signals to their conserved WH2-Central-Acidic (WCA) peptide sequence at the C-terminus, which...

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PMID: 35667337
DOI: 10.1016/j.ejcb.2022.151244

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