Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tryptanthrin Regulates Vascular Smooth Muscle Cell Phenotypic Switching in Atherosclerosis by AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Signaling Pathway.

Journal of cardiovascular pharmacology - 1 May 2021

Shi Xiujin, Zhang Yi, Han Jialun, Peng Wenxing, Fang Zhenwei, Qin Ying, Xu Xiaoyu, Lin Jie, Xiao Fucheng, Zhao Limin, Lin Yang

Abstract excerpt

ABSTRACT: Atherosclerosis (AS) is one of the most severe cardiovascular diseases involved in the phenotypic switching of vascular smooth muscle cells (VSMCs). Tryptanthrin is a natural product with broad biological activities. However, the effect of tryptanthrin on atherosclerotic progression is unclear. The aim of this study was to determine the role of tryptanthrin in AS and explore the potential mechanism. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyl-CoA Carboxylase
Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Becaplermin

Share to Cell Plasticity

Share to Mice, Knockout, ApoE

Share to Myocytes, Smooth Muscle

Share to Neointima

Share to Plaque, Atherosclerotic

Source

Identifiers

PMID: 33951699
DOI: 10.1097/FJC.0000000000001008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tryptanthrin Regulates Vascular Smooth Muscle Cell Phenotypic Switching in Atherosclerosis by AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Signaling Pathway.PMID 33951699Read ↗

Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice.Semantic proximity Read ↗

LncRNA MALAT1 regulates smooth muscle cell phenotype switch via activation of autophagySemantic proximity Read ↗

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress.Semantic proximity Read ↗

Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway.Semantic proximity Read ↗

MTMR7 suppresses the phenotypic switching of vascular smooth muscle cell and vascular intimal hyperplasia after injury via regulating p62/mTORC1-mediated glucose metabolismSemantic proximity Read ↗

7-O-methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells.Semantic proximity Read ↗

Metformin Inhibits the Phenotypic Transformation of Aortic Vascular Smooth Muscle Cells Induced by Hyperglycemia Through Regulation of the Mir-21-mediated PTEN/pAKT/Egr-1 PathwaySemantic proximity Read ↗

N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula Rat Model.Semantic proximity Read ↗

TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation.Semantic proximity Read ↗

Deficiency of protein inhibitor of activated STAT3 exacerbates atherosclerosis by modulating VSMC phenotypic switching.Semantic proximity Read ↗

Atorvastatin regulates vascular smooth muscle cell phenotypic transformation by epigenetically modulating contractile proteins and mediating Akt/FOXO4 axis.Semantic proximity Read ↗

AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.