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Metformin Inhibits the Phenotypic Transformation of Aortic Vascular Smooth Muscle Cells Induced by Hyperglycemia Through Regulation of the Mir-21-mediated PTEN/pAKT/Egr-1 Pathway

2021-09-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> The phenotypic transformation of arterial vascular smooth muscle cells (VSMC) is one of the key mechanisms in the formation of atherosclerotic plaque. It is unclear whether metformin can inhibit the phenotypic transformation of VSMC. In this study, we observed the effect of metformin on the phenotypic transformation of VSMC in vivo and in vitro and its mechanism....

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Literature Corpus work: c5858053-0a9c-5a44-bb7e-f1f5dfebb921
DOI: 10.21203/rs.3.rs-907826/v1

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Metformin Inhibits the Phenotypic Transformation of Aortic Vascular Smooth Muscle Cells Induced by Hyperglycemia Through Regulation of the Mir-21-mediated PTEN/pAKT/Egr-1 PathwayDOI 10.21203/rs.3.rs-907826/v1Read

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