Circulating Proteomic Signatures of Chronological Age.

doi:10.1093/gerona/glu121

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Article

Circulating Proteomic Signatures of Chronological Age.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jul 2015

Menni Cristina, Kiddle Steven J, Mangino Massimo, Viñuela Ana, Psatha Maria, Steves Claire, Sattlecker Martina, Buil Alfonso, Newhouse Stephen, Nelson Sally, Williams Stephen, Voyle Nicola, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Spector Tim D, Dobson Richard, Valdes Ana M

Abstract excerpt

To elucidate the proteomic features of aging in plasma, the subproteome targeted by the SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort. Findings were replicated in 677 independent individuals from the AddNeuroMed, Alzheimer's Research UK, and Dementia Case Registry cohorts. Results were further validated using RNAseq data from whole blood in TwinsUK and the most significant...

Topics

Adult
Aged
Aged, 80 and over
Aging
Biomarkers
Carrier Proteins
Cohort Studies
Cytokines
Eye Proteins
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Insulin-Like Growth Factor Binding Protein 6

Male

Matrix Metalloproteinase 12

Middle Aged

Nerve Tissue Proteins

Phenotype

Proteomics

Source

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Identifiers

PMID: 25123647
DOI: 10.1093/gerona/glu121
PMCID: PMC4469006

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