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Article

Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Feb 2003

Dorne J L C M, Walton K, Renwick A G

Abstract excerpt

CYP3A4 constitutes the major liver cytochrome P450 isoenzyme and is responsible for the oxidation of more than 50% of all known drugs. Human variability in kinetics for this pathway has been quantified using a database of 15 compounds metabolised extensively (>60%) by this CYP isoform in order to...

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PMID: 12480298
DOI: 10.1016/s0278-6915(02)00209-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12480298-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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