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Influence of CYP2D6, CYP3A4, CYP3A5 and ABCB1 Polymorphisms on Pharmacokinetics and Safety of Aripiprazole in Healthy Volunteers.

Basic & clinical pharmacology & toxicology - 1 Jun 2018

Belmonte Carmen, Ochoa Dolores, Román Manuel, Saiz-Rodríguez Miriam, Wojnicz Aneta, Gómez-Sánchez Clara Isabel, Martín-Vílchez Samuel, Abad-Santos Francisco

Abstract excerpt

The aim of this study was to investigate the effect of polymorphisms in cytochrome P450 (CYP) 2D6, CYP3A4 and CYP3A5 enzymes and in P-glycoprotein (P-gp) on the pharmacokinetics and safety of aripiprazole and, its active metabolite, dehydro-aripiprazole, in 148 healthy volunteers from six bioequivalence trials receiving a single oral dose of aripiprazole. The plasma concentrations of both analytes were measured...

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Source

Identifiers

PMID: 29325225
DOI: 10.1111/bcpt.12960

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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