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Article

Flavin-Containing Monooxygenase 3 Polymorphic Variants Significantly Affect Clearance of Tamoxifen and Clomiphene.

Basic & clinical pharmacology & toxicology - 1 Dec 2018

Catucci Gianluca, Bortolussi Stefania, Rampolla Giulia, Cusumano Debora, Gilardi Gianfranco, Sadeghi Sheila J

Abstract excerpt

Human flavin-containing monooxygenase 3 (hFMO3) is a drug-metabolising enzyme that oxygenates many drugs and xenobiotics in the liver. This enzyme is also known to exhibit single nucleotide polymorphisms (SNPs) that can alter the rates of monooxygenation of therapeutic agents. The purpose of this study was to investigate the effect of the three common polymorphic variants of hFMO3 (V257M, E158K and E308G) on the...

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PMID: 29959872
DOI: 10.1111/bcpt.13089

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