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Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans

21 Aug 2020

Abstract excerpt

Human CYP3A enzymes (including CYP3A4 and CYP4A5) metabolize about 30% of all drugs and numerous other environmental and endogenous substances. CYP3A activity is highly variable within and between humans. As a consequence, therapy with standard doses often results in too low or too high blood and tissue concentrations resulting in therapeutic failure or dose-related adverse reactions. It is an unanswered question...

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PMID: 32973880
DOI: 10.3389/fgene.2020.00944

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