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Article

Identification of homozygous haplotypes carrying putative recessive lethal mutations that compromise fertility traits in French Lacaune dairy sheep.

Genetics, selection, evolution : GSE - 1 May 2021

Ben Braiek Maxime, Fabre Stéphane, Hozé Chris, Astruc Jean-Michel, Moreno-Romieux Carole

Abstract excerpt

BACKGROUND: Homozygous recessive deleterious mutations can cause embryo/fetal or neonatal lethality, or genetic defects that affect female fertility and animal welfare. In livestock populations under selection, the frequency of such lethal mutations may increase due to inbreeding, genetic drift, and/or the positive pleiotropic effects of heterozygous carriers on selected traits. RESULTS: By scanning the genome of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33932977
DOI: 10.1186/s12711-021-00634-1
PMCID: PMC8088666

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