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Article

Deficiency in homozygous haplotypes reveals recessive lethal variants affecting fertility and viability in the Friesian horse.

BMC genomics - 11 Mar 2026

Steensma Marije J, Ducro Bart J, Doekes Harmen P, Dibbits Bert, Groenen Martien A M, Derks Martijn F L

Abstract excerpt

BACKGROUND: Recessive lethal alleles causing pre- or postnatal death in homozygous mutant animals, could lead to reduced fertility success. The Friesian horse breed has signs of reduced fertility and has faced high inbreeding rates in the past (∆F > 1%). Consequently, by genetic drift lethal alleles may have reached moderate to high frequencies in the population. Our aim was to identify lethal recessive alleles...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41808016
DOI: 10.1186/s12864-026-12728-5
PMCID: PMC13088515

Genes

MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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