Harmful recessive effects on fertility detected by absence of homozygous haplotypes.

doi:10.3168/jds.2011-4624

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Article

Harmful recessive effects on fertility detected by absence of homozygous haplotypes.

Journal of dairy science - 1 Dec 2011

VanRaden P M, Olson K M, Null D J, Hutchison J L

Abstract excerpt

Five new recessive defects were discovered in Holsteins, Jerseys, and Brown Swiss by examining haplotypes that had a high population frequency but were never homozygous. The method required genotypes only from apparently normal individuals and not from affected embryos. Genotypes from the BovineSNP50 BeadChip (Illumina, San Diego, CA) were examined for 58,453 Holsteins, 5,288 Jerseys, and 1,991 Brown Swiss with...

Topics

Animals
Cattle
Cattle Diseases
Female
Fertilization
Genes, Lethal
Genes, Recessive
Genetic Markers
Genotype
Haplotypes
Heterozygote
Homozygote
Infertility
Male
Phenotype

Source

Open in PubMed

Identifiers

PMID: 22118103
DOI: 10.3168/jds.2011-4624

Provenance

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