Article
Candidate lethal haplotypes and causal mutations in Angus cattle.
BMC genomics - 18 Oct 2017
Hoff Jesse L, Decker Jared E, Schnabel Robert D, Taylor Jeremy F
Abstract excerpt
BACKGROUND: If unmanaged, high rates of inbreeding in livestock populations adversely impact their reproductive fitness. In beef cattle, historical selection strategies have increased the frequency of several segregating fatal autosomal recessive polymorphisms. Selective breeding has also decreased the extent of haplotypic diversity genome-wide. By identifying haplotypes for which homozygotes are not observed but...
Topics
- Animals
- Cattle
- Female
- Haplotypes
- Homozygote
- Male
- Mutation
- Pedigree
- Sequence Analysis