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p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis

24 Jun 2020

Abstract excerpt

KRAS is mutated in most pancreatic ductal adenocarcinomas (PDAC) and yet remains undruggable. Here, we report that p38γ MAPK, which promotes PDAC tumorigenesis by linking KRAS signaling and aerobic glycolysis (also called the Warburg effect), is a novel therapeutic target. p38γ interacted with a glycolytic activator PFKFB3 that was dependent on mutated KRAS. KRAS transformation and overexpression of p38γ...

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PMID: 32580961
DOI: 10.1158/0008-5472.can-19-3281

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