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PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells.

Molecular and cellular biochemistry - 1 Jul 2020

Ozcan Selahattin C, Sarioglu Aybike, Altunok Tugba H, Akkoc Ahmet, Guzel Saime, Guler Sabire, Imbert-Fernandez Yoannis, Muchut Robertino J, Iglesias Alberto A, Gurpinar Yunus, Clem Amy L, Chesney Jason A, Yalcin Abdullah

Abstract excerpt

Tumor cells increase glucose metabolism through glycolysis and pentose phosphate pathways to meet the bioenergetic and biosynthetic demands of rapid cell proliferation. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are key regulators of glucose metabolism via their synthesis of fructose-2,6-bisphosphate (F2,6BP), a potent activator of glycolysis. Previous studies have reported the...

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PMID: 32415418
DOI: 10.1007/s11010-020-03751-5

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