A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia.

doi:10.1038/s41467-021-22625-y

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Article

A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia.

Nature communications - 30 Apr 2021

Docking T Roderick, Parker Jeremy D K, Jädersten Martin, Duns Gerben, Chang Linda, Jiang Jihong, Pilsworth Jessica A, Swanson Lucas A, Chan Simon K, Chiu Readman, Nip Ka Ming, Mar Samantha, Mo Angela, Wang Xuan, Martinez-Høyer Sergio, Stubbins Ryan J, Mungall Karen L, Mungall Andrew J, Moore Richard A, Jones Steven J M, Birol İnanç, Marra Marco A, Hogge Donna, Karsan Aly

Abstract excerpt

As more clinically-relevant genomic features of myeloid malignancies are revealed, it has become clear that targeted clinical genetic testing is inadequate for risk stratification. Here, we develop and validate a clinical transcriptome-based assay for stratification of acute myeloid leukemia (AML). Comparison of ribonucleic acid sequencing (RNA-Seq) to whole genome and exome sequencing reveals that a standalone...

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PMID: 33931648
DOI: 10.1038/s41467-021-22625-y
PMCID: PMC8087683

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