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The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia

9 Mar 2020

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, and implementation of risk-adapted therapy has been instrumental in the dramatic improvements in clinical outcomes. A key to risk-adapted therapies includes the identification of genomic features of individual tumors, including chromosome number (for hyper- and hypodiploidy) and gene fusions, notably ETV6-RUNX1, TCF3-PBX1, and BCR-ABL1 in...

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PMID: 32150610
DOI: 10.1182/bloodadvances.2019001008

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