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Article

Colorectal cancers mimic structural organization of normal colonic crypts.

PloS one - 1 Jan 2014

Cernat Laura, Blaj Cristina, Jackstadt Rene, Brandl Lydia, Engel Jutta, Hermeking Heiko, Jung Andreas, Kirchner Thomas, Horst David

Abstract excerpt

Colonic crypts are stereotypical structures with distinct stem cell, proliferating, and differentiating compartments. Colorectal cancers derive from colonic crypt epithelia but, in contrast, form morphologically disarrayed glands. In this study, we investigated to which extent colorectal cancers phenocopy colonic crypt architecture and thus preserve structural organization of the normal intestinal epithelium. A...

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Identifiers

PMID: 25111606
DOI: 10.1371/journal.pone.0104284
PMCID: PMC4128715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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