Article
Common variants in human CRC genes as low-risk alleles.
European journal of cancer (Oxford, England : 1990) - 1 Apr 2010
Picelli Simone, Zajac Pawel, Zhou Xiao-Lei, Edler David, Lenander Claes, Dalén Johan, Hjern Fredrik, Lundqvist Nils, Lindforss Ulrik, Påhlman Lars, Smedh Kennet, Törnqvist Anders, Holm Jörn, Janson Martin, Andersson Magnus, Ekelund Susanne, Olsson Louise, Lundeberg Joakim, Lindblom Annika
Abstract excerpt
The genetic susceptibility to colorectal cancer (CRC) has been estimated to be around 35% and yet high-penetrance germline mutations found so far explain less than 5% of all cases. Much of the remaining variations could be due to the co-inheritance of multiple low penetrant variants. The identification of all the susceptibility alleles could have public health relevance in the near future. To test the hypothesis...
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