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Article

Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer.

Journal of the National Cancer Institute - 1 Feb 2016

Kastrinos Fay, Ojha Rohit P, Leenen Celine, Alvero Carmelita, Mercado Rowena C, Balmaña Judith, Valenzuela Irene, Balaguer Francesc, Green Roger, Lindor Noralane M, Thibodeau Stephen N, Newcomb Polly, Win Aung Ko, Jenkins Mark, Buchanan Daniel D, Bertario Lucio, Sala Paola, Hampel Heather, Syngal Sapna, Steyerberg Ewout W

Abstract excerpt

BACKGROUND: Recent guidelines recommend the Lynch Syndrome prediction models MMRPredict, MMRPro, and PREMM1,2,6 for the identification of MMR gene mutation carriers. We compared the predictive performance and clinical usefulness of these prediction models to identify mutation carriers. METHODS: Pedigree data from CRC patients in 11 North American, European, and Australian cohorts (6 clinic- and 5 population-based...

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Source

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Identifiers

PMID: 26582061
DOI: 10.1093/jnci/djv308
PMCID: PMC4862416

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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