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Article

Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 2017

Kastrinos Fay, Uno Hajime, Ukaegbu Chinedu, Alvero Carmelita, McFarland Ashley, Yurgelun Matthew B, Kulke Matthew H, Schrag Deborah, Meyerhardt Jeffrey A, Fuchs Charles S, Mayer Robert J, Ng Kimmie, Steyerberg Ewout W, Syngal Sapna

Abstract excerpt

Purpose Current Lynch syndrome (LS) prediction models quantify the risk to an individual of carrying a pathogenic germline mutation in three mismatch repair (MMR) genes: MLH1, MSH2, and MSH6. We developed a new prediction model, PREMM5, that incorporates the genes PMS2 and EPCAM to provide comprehensive LS risk assessment. Patients and Methods PREMM5 was developed to predict the likelihood of a mutation in any of...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to Epithelial Cell Adhesion Molecule

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Logistic Models

Share to Mismatch Repair Endonuclease PMS2

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Source

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Identifiers

PMID: 28489507
DOI: 10.1200/JCO.2016.69.6120
PMCID: PMC5493047

Genes

PMS2
EPCAM
MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome.PMID 28489507Read ↗

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A comparison of models used to predict MLH1, MSH2 and MSH6 mutation carriers.Semantic proximity Read ↗

Prediction of MLH1 and MSH2 mutations in Lynch syndrome.Semantic proximity Read ↗

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