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Article

Inhibition of glypican-1 expression induces an activated fibroblast phenotype in a human bone marrow-derived stromal cell-line.

Scientific reports - 29 Apr 2021

Kaur Sukhneeraj P, Verma Arti, Lee Hee K, Barnett Lillie M, Somanath Payaningal R, Cummings Brian S

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are the most abundant stromal cell type in the tumor microenvironment. CAFs orchestrate tumor-stromal interactions, and contribute to cancer cell growth, metastasis, extracellular matrix (ECM) remodeling, angiogenesis, immunomodulation, and chemoresistance. However, CAFs have not been successfully targeted for the treatment of cancer. The current study elucidates the...

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Identifiers

PMID: 33927256
DOI: 10.1038/s41598-021-88519-7
PMCID: PMC8084937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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