Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation

13 Oct 2014

Abstract excerpt

Myofibroblasts are a key cell type in wound repair, cardiovascular disease, and fibrosis and in the tumor-promoting microenvironment. The high accumulation of myofibroblasts in reactive stroma is predictive of the rate of cancer progression in many different tumors, yet the cell types of origin and the mechanisms that regulate proliferation and differentiation are unknown. We report here, for the first time to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Mesenchymal stem cell research
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25313057
DOI: 10.1073/pnas.1407097111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiationPMID 25313057Read ↗

Therapeutic implications of cancer stem cells in prostate cancerSemantic proximity Read ↗

PDGFRα <sup>+</sup> Mesenchymal Stromal Cells Contribute to Epithelial Lineages during Prostate DevelopmentSemantic proximity Read ↗

Mesenchymal stem cells and prostate cancer: A concise review of therapeutic potentials and biological aspectsSemantic proximity Read ↗

Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblastsSemantic proximity Read ↗

Aberrant Transforming Growth Factor-β Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia.Semantic proximity Read ↗

SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells.Semantic proximity Read ↗

Inhibition of glypican-1 expression induces an activated fibroblast phenotype in a human bone marrow-derived stromal cell-line.Semantic proximity Read ↗

Conditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer.Semantic proximity Read ↗

TGFβ signaling limits lineage plasticity in prostate cancer.Semantic proximity Read ↗

Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasisSemantic proximity Read ↗

PDGF, TGF-β, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineagesSemantic proximity Read ↗

Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.