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Article

Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.

The Prostate - 1 Jul 2007

Horvath Lisa G, Lelliott Jayne E, Kench James G, Lee C-Soon, Williams Elizabeth D, Saunders Darren N, Grygiel John J, Sutherland Robert L, Henshall Susan M

Abstract excerpt

BACKGROUND: Secreted frizzled-related proteins (sFRP4) inhibits Wnt signaling and thus cellular proliferation in androgen-independent prostate cancer cells in vitro. However, increased expression of membranous sFRP4 is associated with a good prognosis in human localized androgen-dependent prostate cancer, suggesting a role for sFRP4 in early stage disease. Here, we investigated the phenotype of sFRP4...

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PMID: 17476687
DOI: 10.1002/pros.20607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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