Silibinin prevents prostate cancer cell‐mediated differentiation of naïve fibroblasts into cancer‐associated fibroblast phenotype by targeting TGF β2

Abstract excerpt

Tumor microenvironment (TM) is an essential element in prostate cancer (PCA), offering unique opportunities for its prevention. TM includes naïve fibroblasts that are recruited by nascent neoplastic lesion and altered into 'cancer-associated fibroblasts' (CAFs) that promote PCA. A better understanding and targeting of interaction between PCA cells and fibroblasts and inhibiting CAF phenotype through non-toxic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone health and treatments
• Share to Oral health in cancer treatment
• Share to Silymarin and Mushroom Poisoning