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Article

SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells.

Cells - 16 Dec 2022

Akova Ölken Elif, Aszodi Attila, Taipaleenmäki Hanna, Saito Hiroaki, Schönitzer Veronika, Chaloupka Michael, Apfelbeck Maria, Böcker Wolfgang, Saller Maximilian Michael

Abstract excerpt

Prostate cancer bone metastasis is still one of the most fatal cancer diagnoses for men. Survival of the circulating prostate tumor cells and their adaptation strategy to survive in the bone niche is the key point to determining metastasis in early cancer stages. The promoter of SFRP2 gene, encoding a WNT signaling modulator, is hypermethylated in many cancer types including prostate cancer. Moreover, SFRP2 can...

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PMID: 36552843
DOI: 10.3390/cells11244081
PMCID: PMC9777425

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