MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.

doi:10.3390/genes12040587

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Article

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.

Genes - 17 Apr 2021

Petrone Igor, Bernardo Paula Sabbo, Dos Santos Everton Cruz, Abdelhay Eliana

Abstract excerpt

Folate (vitamin B9) is found in some water-soluble foods or as a synthetic form of folic acid and is involved in many essential biochemical processes. Dietary folate is converted into tetrahydrofolate, a vital methyl donor for most methylation reactions, including DNA methylation. 5,10-methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate metabolism pathway that converts...

Topics

Brain Neoplasms
Breast Neoplasms
DNA Methylation
Female
Folic Acid
Genetic Predisposition to Disease
Glioma
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Single Nucleotide
Stomach Neoplasms

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Identifiers

PMID: 33920562
DOI: 10.3390/genes12040587
PMCID: PMC8073588

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