Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.

Genes - 17 Apr 2021

Petrone Igor, Bernardo Paula Sabbo, Dos Santos Everton Cruz, Abdelhay Eliana

Abstract excerpt

Folate (vitamin B9) is found in some water-soluble foods or as a synthetic form of folic acid and is involved in many essential biochemical processes. Dietary folate is converted into tetrahydrofolate, a vital methyl donor for most methylation reactions, including DNA methylation. 5,10-methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate metabolism pathway that converts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Breast Neoplasms
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Folic Acid

Share to Glioma

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 33920562
DOI: 10.3390/genes12040587
PMCID: PMC8073588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.PMID 33920562Read ↗

A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk.Semantic proximity Read ↗

Association between MTHFR 677C>T polymorphism and risk of gliomas: evidence from a meta-analysis.Semantic proximity Read ↗

Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan.Semantic proximity Read ↗

MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study.Semantic proximity Read ↗

Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.Semantic proximity Read ↗

Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease.Semantic proximity Read ↗

Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.Semantic proximity Read ↗

Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.Semantic proximity Read ↗

Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response.Semantic proximity Read ↗

Role of the MTHFR polymorphisms in cancer risk modification and treatment.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.