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Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan.

Carcinogenesis - 1 Nov 2006

Chou Yu-Ching, Wu Mei-Hsuan, Yu Jyh-Cherng, Lee Meei-Shyuan, Yang Tsan, Shih Hsiu-Lan, Wu Tsai-Yi, Sun Chien-An

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one-carbon metabolism for DNA synthesis and methylation, both are implicated in carcinogenesis. Two common variants in the MTHFR gene (C677T and A1298C) have been associated with reduced enzyme activity, thereby making MTHFR polymorphisms a potential candidate cancer-predisposing factor. To evaluate the C677T and A1298C...

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Identifiers

PMID: 16777985
DOI: 10.1093/carcin/bgl108

Genes

MTHFR

Variants

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