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Article

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.

European journal of medical genetics - 1 Jan 2015

Liew Siaw-Cheok, Gupta Esha Das

Abstract excerpt

The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) with the epidemiology of the polymorphism of the C677T that varies dependent on the geography and ethnicity. The 5,10-Methylenetetrahydrofolate reductase (MTHFR) locus is mapped on chromosome 1 at the end of the short arm (1p36.6). This enzyme is important...

Topics

Diabetes Mellitus
Folic Acid
Genetic Predisposition to Disease
Homocysteine
Humans
Infertility
Mental Disorders
Methylenetetrahydrofolate Reductase (NADPH2)
Neoplasms
Nervous System Diseases
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Psoriasis

Vascular Diseases

Vitamin B 12

Source

Identifiers

PMID: 25449138
DOI: 10.1016/j.ejmg.2014.10.004

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25449138-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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