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Article

Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Nov 2015

Xie Shu-Zhe, Liu Zhi-Zhong, Yu Jun-hua, Liu Li, Wang Wei, Xie Dao-Lin, Qin Jiang-Bo

Abstract excerpt

Many molecular epidemiological studies have been performed to explore the association between MTHFR C677T polymorphism and cancer risk in diverse populations. However, the results were inconsistent. Hence, we performed a meta-analysis to investigate the association between cancer risk and MTHFR C677T (150,086 cases and 200,699 controls from 446 studies) polymorphism. Overall, significantly increased cancer risk...

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Source

Identifiers

PMID: 26081619
DOI: 10.1007/s13277-015-3648-z

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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