Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.

doi:10.1093/aje/kwm344

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Article

Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.

American journal of epidemiology - 1 Mar 2008

Boccia Stefania, Hung Rayjean, Ricciardi Gualtiero, Gianfagna Francesco, Ebert Matthias P A, Fang Jing-Yuan, Gao Chang-Ming, Götze Tobias, Graziano Francesco, Lacasaña-Navarro Marina, Lin Dongxin, López-Carrillo Lizbeth, Qiao You-Lin, Shen Hongbing, Stolzenberg-Solomon Rachael, Takezaki Toshiro, Weng Yu-Rong, Zhang Fang Fang, van Duijn Cornelia M, Boffetta Paolo, Taioli Emanuela

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial. The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies,...

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PMID: 18162478
DOI: 10.1093/aje/kwm344

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MTHFR

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