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Article

Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2015

Lu Qing, Jiang Ke, Li Qiong, Ji Ya-Jie, Chen Wei-Li, Xue Xiao-Hong

Abstract excerpt

Breast cancer is the most common cancer affecting women in China and the world. Folate supplementation is proven to be effective in reducing the risk of breast cancer or improving its prognosis. Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism and DNA synthesis. This study aims to examine whether single nucleotide polymorphisms (SNP) in the MTHFR gene are associated...

Topics

Adult
Aged
Breast Neoplasms
China
Female
Folic Acid
Genetic Association Studies
Genotype
Haplotypes
Humans
Methylenetetrahydrofolate Reductase (NADPH2)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymorphism, Single Nucleotide

Prognosis

Risk Factors

Survival Analysis

Source

Identifiers

PMID: 25566964
DOI: 10.1007/s13277-014-3016-4

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population.PMID 25566964Read ↗

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